This book gathers a selection of peer-reviewed research papers presented at the joint IV ASOCIO/XIX IISE Region 16 Conference held in Chia and Bogota, Colombia. The conference was organized by the Universidad de La Sabana’s Research Group on Logistics Systems, in partnership with Chapters #782 (Universidad de La Sabana), #712 (Universidad Sergio Arboleda) and #988 (Universidad de Los Andes) of the Institute of Industrial and Systems Engineers (IISE). The main emphasis of the book is on modelling and solving business-related problems in operations research, and on applying descriptive, predictive and prescriptive analytics and the management sciences to actual decision-making in organizations. Both theoretical developments and algorithm implementation are presented. A special focus is given to business problems arising in emerging economies, particularly in Latin America and the Caribbean. This book is addressed to academics, practitioners, postgraduate students and researchers in operations research, analytics and industrial engineering, as well as to undergraduate students for educational purposes. In particular, the book will appeal to the academic and research community in Latin America and the Caribbean, as it presents projects developed and implemented there. Higher education engineering programs will benefit from the findings and insights shared in the fields of industrial engineering, operations research and analytics, applied mathematics, and computer science and engineering.