Extensively revised, this text explores the biomaterials aspects of research on and treatment of injuries, disabilities, and diseases of the musculoskeletal system, emphasizing properties of natural soft and hard tissues and of materials used to replace or treat them, and the interactions between native tissues and man-made (engineered) materials. It is intended for use in both teaching and self-study settings. The work introduces materials science as applied to medical research and treatment (biomaterials) for students and practitioners who may lack formal training in engineering.