Available open access digitally under CC-BY licence. Pre-exposure prophylaxis (PrEP) is a drug taken by HIV-negative people that reduces the risk of getting HIV. Comparing two case studies in Denmark and Zimbabwe, this book demonstrates six paradoxes that users often encounter in navigating their PrEP journey. These paradoxes lead to contentions, uncertainties, dilemmas and ambiguities that need to be carefully and pensively responded to through what the author terms ‘everyday PrEP negotiations’. The social nature and need for such everyday PrEP negotiations help explain why PrEP works for some people and not for others. This book argues that such insight is critical to make PrEP work for more people and to inform social public health responses.