This text provides a comprehensive guidebook for the physical rehabilitation of musculoskeletal pain and injury. An evidence-based perspective grounds the scientific foundations and clinical application to present a contemporary model of care. Integrated into this evidence-informed perspective are clinical pearls offered by master clinicians who have developed tips and techniques to assist individuals in the recovery process for some of the most common musculoskeletal conditions. Physical Rehabilitation for Musculoskeletal Conditions integrates foundational principles such as the clinical reasoning approach, exercise dosing, and prescription, along with modern perspectives in pain science, threaded throughout the text. These principles are applied with specific examples for a variety of patient demographics, from young athletes engaged in recovery from sports injuries to older adults and post-surgical patient cases. Individual chapters provide a regional approach to manual therapy techniques, followed by exercise progressions across the most common musculoskeletal conditions in clinical practice. This text features the integration of modern techniques, such as blood flow restriction training and dry needling, with supportive scientific evidence. This textbook is for clinicians and students who will be managing individuals with various musculoskeletal pain conditions across all body regions, including the extremity joints, spine, and temporomandibular joints. Current physical therapy, athletic training, and other healthcare students will appreciate the in-depth technique, exercise photographs, and detailed descriptions. The foundational structure across the entire musculoskeletal system and the modern evidence-informed approach offered by this textbook make it an excellent resource for classroom learning.