In this issue of Infectious Disease Clinics of North America, guest editors Drs. Keith S. Kaye and Sorabh Dhar bring their considerable expertise to the topic of Infection Prevention and Control in Healthcare, Part 2. In the next five years, it is anticipated that healthcare facilities will continue to evolve by integrating advanced technologies and infrastructure improvements to strengthen IPC programs, adopting innovative solutions to monitor and control infections. In this Part Two issue, top experts provide state-of-the-art information to infectious disease clinicians on these innovations in preventing healthcare-associated infections. Contains 12 relevant, practice-oriented topics including prevention of Clostridium difficile in healthcare; infection control processes to prevent the spread of tuberculosis in the hospital; infection prevention for fungal infections; the role of infection prevention in monitoring and preventing hospital-acquired viral respiratory infection; roles and processes for pandemic preparedness in infection control; and more. Provides in-depth clinical reviews on infection prevention and control in healthcare, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.