These proceedings gather contributions presented at the 3rd International Conference of Mechatronics and Cyber-MixMechatronics/ICOMECYME, organized by the National Institute of R&D in Mechatronics and Measurement Technique in Bucharest, Romania, on September 5th–6th, 2019. Reflecting the expansion mechatronics, it discusses topics in the newer trans-disciplinary fields, such as adaptronics, integronics, and cyber-mixmechatronics. With a rich scientific tradition and attracting specialists from around the globe – including North America, South America, and Asia – ICOMECYME focuses on presenting the latest research. It is mainly directed at academics and advanced students, but also appeals to R&D experts, offering a platform for scientific exchange. These proceedings are a valuable resource for entrepreneurs who want to invest in research and who are open for collaborations.