In this issue of Pediatric Clinics of North America, guest editors Drs. Steven P. Miller and Thiviya Selvanathan bring their considerable expertise to the topic of Promoting Brain Development in the Neonate. Promoting healthy early brain development is critical to promoting long-term neurodevelopmental outcomes in all newborns, particularly those at high risk for neurodevelopmental impairments. This issue reviews recent advances in neonatal neurology while also highlighting key gaps that exist in the literature. Articles specifically focus on how brain injury, environmental and infectious exposures, and clinical care in the NICU all impact early brain development. Contains 13 relevant, practice-oriented topics, including neonatal neurocritical care; advances in preterm brain injury; social determinants of health; prenatal opioid exposure; the effects of climate change on pediatric health; and moreProvides in-depth clinical reviews on promoting brain development in the neonate, offering actionable insights for clinical practicePresents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews