This edited book is based on the accepted papers for presentation at the 1st MedGU Annual Meeting, Istanbul 2021. With four parts spanning a large spectrum of geological, geochemical, geophysical and petroleum topics, this book presents a series of newest research studies that are nowadays relevant to Middle East, Mediterranean region, and Africa. The book covers various topics from the fields of (1) sedimentology, stratigraphy, paleontology, (2) geochemistry, mineralogy, petrology, volcanology, (3) structural geology, tectonics, geodynamics, and (4) petroleum and energy engineering, and petroleum geology. The content of these papers provides new scientific knowledge for further understanding new case studies and approaches in these various topics.