The book offers a transdisciplinary eco-systemic framework for analysis of ecosystems. It uses eight dimensions (economic-social-political-environmen-tal) and 40 factors to diagnose degenerating ecosystems and to synthesize regenerative ecosystems amid growing uncertainty, and inequality in the Anthropocene. Chapter 1 broadly defines the `all interacting evolving systems science' (AIESS) approach in terms of its eco-systemic and transdisciplinary action research methodology. Chapter 2 provides a detailed explanation of the AIESS approach  through the four concepts of interconnectedness, interdependence, interactions, and intent to diagnose degeneration and synthesize regenerative systems. Part 1 of the book discusses the issues and approaches to Regenerativeness. Part 2, 3, 4, and 5 illustrate cases of regenerative systems in different ecosystems viz. natural, rural-indigenous, urban, and industrial ecosystems. Not only the researchers and scholarsin systems science, systems dynamics, systems design, and sustainable transition strategies but also the policy makers, corporate leaders, and development experts will greatly benefit from this book. 1. Presents a ground breaking explanation of the science of change in the Anthropocene and in epochs prior to it through its all interacting evolving systems science framework. 2. Provides a unique transdisciplinary eco-systemic framework as a methodology to diagnose the complex degenerating ecosystems and to synthesize regenerative ecosystems in different geographies of the world. 3. Through various cases from different ecosystems viz., natural ecosystems, rural-indigenous ecosystems, urban ecosystems, and industrial ecosystems, the book presents the challenges as well as the steps and processes to synthesize regenerative ecosystems.