First published in 1999, this volume addresses various themes in regional development studies from the perspective of structural economic change. Particular attention is paid to factors having long-run implications for regional development, such as innovation and knowledge production. Innovation and research and development activities appear to take place at particular locations. This has implications for long-run spatial and sectoral developments. Another factor is transport infrastructure; its impact on efficiency and equity is surveyed. Other themes covered relate to the role of tourism and adjustments in urban economies. The books aims to offer a balance between modelling and non-modelling approaches. In addition to country-specific contributions, some are offered at the European level.