Infrastructure that manages our water resources (such as, dams and reservoirs, irrigation systems, channels, navigation waterways, water and wastewater treatment facilities, storm drainage systems, urban water distribution and sanitation systems), are critical to all sectors of an economy. Realizing the importance of water infrastructures, efforts have already begun on understanding the sustainability and resilience of such systems under changing conditions expected in the future. The goal of this collected work is to raise awareness among civil engineers of the various implications of landscape change and non-climate drivers on the resilience of water management infrastructure. It identifies the knowledge gaps and then provides effective and complementary approaches to assimilate knowledge discovery on local (mesoscale)-to-regional landscape drivers to improve practices on design, operations and preservation of large water infrastructure systems.