Research in this book enhances the understanding of small and medium-sized businesses as a result of unprecedented challenges presented to them. It elaborates on how some small and medium-sized businesses not only survive, but also thrive amidst uncertainties, by embracing digital solutions or transformations. To achieve this, the book adopts mixed research methods, with a combination of case studies, secondary data analysis and primary data analysis (survey information and/or interviews). Tables and illustrations are also included to provide the reader with a holistic understanding of small and medium-sized businesses from different cultural contexts.