This book identifies the driving forces behind globalization and proposes innovative ways for small and medium-enterprises (SMEs) to confront them. More than ever, sustainable competitive advantage requires SMEs to continually adapt their strategy and confront new and current competition in the international market. SMEs working with multinational companies could also benefit from winning strategies based on a sensible analysis of rational and irrational phenomena at the micro- and macro-economic levels. This book uses different models developed and established through international business experiences to determine the relevant  strategy in the global market. It illustrates each model through real, successful case studies of globalization of factor, efficiency, and innovation-driven SMEs. It will benefit scholars of entrepreneurship, international business, regional development as well as managers, governmental institutions, and regional development, and consultants to SMEs.