This book constitutes the proceedings of the 41st International Conference on Current Trends in Theory and Practice of Computer Science held in Pec pod Snežkou, Czech Republic, during January 24-29, 2015. The book features 8 invited talks and 42 regular papers which were carefully reviewed and selected from 101 submissions. The papers are organized in topical sections named: foundations of computer science; software and Web engineering; data, information, and knowledge engineering; and cryptography, security, and verification.