In the era of the Internet of Things (IoT) and Digital Twins (DT), network infrastructures are rapidly evolving to meet industrial demands. Thus, we were motivated to explore the changing landscape of network deployment, management and utilization, driven by the rise of connected devices and emerging challenges. Software-defined Infrastructure focuses on the cutting-edge shift in hardware deployment and communication management methods, which enable unified, scalable and adaptive network management to support Healthcare IoT (H-IoT) communication, where real-time data transmission is essential to system success. The book presents a novel network concept and solutions for tackling the challenges in key areas such as 5G, and beyond, in network management, multipath transport protocols and edge computing. This book aims to simplify network management, improve remote patient monitoring communication and enhance patient outcomes. Through case studies and theoretical models, the book offers insights into the transformation of advanced networks in the H-IoT context and lays the foundation for innovative ideas in this research domain.