The present volume contains the Proceedings of the International Conference on Spectral Theory and Mathematical Physics held in Santiago de Chile in November 2014. Main topics are: Ergodic Quantum Hamiltonians, Magnetic Schrödinger Operators, Quantum Field Theory, Quantum Integrable Systems, Scattering Theory, Semiclassical and Microlocal Analysis, Spectral Shift Function and Quantum Resonances. The book presents survey articles as well as original research papers on these topics. It will be of interest to researchers and graduate students in Mathematics and Mathematical Physics.