This volume contains selected papers from the Second Quadrennial International Conference on Structural Integrity (ICONS-2018). The papers cover important topics related to structural integrity of critical installations, such as power plants, aircrafts, spacecrafts, defense and civilian components. The focus is on assuring safety of operations with high levels of reliability and structural integrity. This volume will be of interest to plant operators working with safety critical equipment, engineering solution providers, software professionals working on engineering analysis, as well as academics working in the area.