The aim of this 2-volume book is to highlight how Sustainability Science approaches can help solve some of the pervasive challenges that Africa faces. The volumes collect a number of local case studies throughout Africa that adopt transdisciplinary and problem-oriented research approaches using methodologies from the natural and the social sciences. These are put into perspective with chapters that introduce key sustainability challenges such using a regional focus. Through this multi-scale and inter/transdisciplinary approach the proposed volume will provide an authoritative source that will pack in a single volume a large amount of information on how Sustainability Science approaches sustainability challenges in African contexts. While there have been general books about sustainability science, none has had a strong African focus. As a result the 2-volume set fills a major gap in the Sustainability Science scholarship. This volume sets the stage for the series. PartI introduces key sustainability challenges in Africa. Parts II-III highlights specific case studies related to these challenges from West and Central Africa.