This proceedings book contains research papers that are accepted for presentation at the 16th International Conference on Interdisciplinarity in Engineering—INTER-ENG 2022, which is held on 6–7 October 2022, in the city of Târgu Mureș, Romania. The general scope of the conference "Innovative aspects of Industry 4.0" concepts aims at consolidating the digital future of manufacturing in companies" is propsing a new approach related to the development of a new generation of smart factories grounded on the manufacturing and assembly process digitalization. It is related to advance manufacturing technology, lean manufacturing, sustainable manufacturing, additive manufacturing, manufacturing tools and equipment. It is a leading international professional and scientific forum of great interest for engineers and scientists who can read in this book research works contributions and recent developments as well as current practices in advanced fields of engineering.