This book is an evidence-based guide for some of the most common consult questions asked of a first-year infectious diseases (ID) fellow working in an academic teaching hospital. Divided into sections based on pathogen and organ system, each covered topic includes reviews of the latest published literature in succinct subsections that can be easily referenced. The book can be read cover to cover as an introduction to clinical infectious diseases through the eyes of an ID fellow or used as a reference in real-time when on clinical service.  Written throughout the fellowship of an ID fellow, this handbook  shares the quintessential ID topics most commonly encountered on the consult service. From global pandemics to the emergence of drug-resistant superbugs, interest in infectious diseases has never been higher. ID experts weigh in daily on a variety of cases ranging from simple urinary tract infections to devastating sepsis in patients with recent organ transplantation. The ID consult service can be overwhelming given the breadth of infectious diseases that affect our patients. This handbook offers an introductory yet comprehensive resource to professionals, practitioners, students, and fellows.