This book constitutes the refereed proceedings of the 21st IFIP WG 6.11 Conference on e-Business, e-Services, and e-Society, I3E 2022, which took place Newcastle-upon-Tyne, UK, in September 2022. The 37 papers presented in this volume were carefully reviewed and selected from 72 submissions. They were organized in topical sections as follows: Artificial intelligence; Data and Analytics; Careers and ICT; Digital Innovation and Transformation; Electronic Services; Health and Wellbeing; Pandemic; Privacy, Trust and Security.