This book discloses the cause-and-effect relationships between the sustainable development of the entrepreneurial economy and the new market and technological context in the Fifth Industrial Revolution. It substantiates the differences between the conditions of the Fifth Industrial Revolution and the Fourth Industrial Revolution. The most important of these differences is the increased attention to the social and environmental aspects of entrepreneurial activities. The reason is that they are most subject to crises and they have the possibility of having more flexible and intense application of the leading digital technologies to the practices of ensuring entrepreneurship sustainability.This book puts forward the original idea that Industry 5.0 is studied not as a factor of sustainable development of the national economy but as a unique market and technological environment for the sustainable development of business economic subjects — entrepreneurial economy. Significantly, the book offers scientific and practical recommendations to improving state and corporate management of the sustainable development of entrepreneurial economy in the context of the Fifth Industrial Revolution.