The rapid development of new technologies in the industry of the future implies a major evolution in the industrial safety measures needed to be met, such as societal requirements. Towards Process Safety 4.0 in the Factory of the Future presents the concept of Safety 4.0 from the point of view of process safety, occupational safety and health, as well as systems’ cyber security. Numerous examples illustrate the different approaches of the identified methods and techniques of Safety 4.0. Their concepts, paradigms, structural bases, couplings, complexities and flaws are systematically analyzed. This comprehensive approach to Safety 4.0 is aimed at the wide variety of actors working in the industry of the future.