Transposable Elements in Health and Disease, Volume 116 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting comprehensive chapters on a variety of timely topics. Specific chapters examine Transposable Elements in Human Cancer: Regulation, Activation, and Genomic Consequences, Retrotransposons as both “architects” and “saboteurs” in the nervous system, Shaping Mammalian Genomes: The Regulation and Co-option of Transposable Elements, Transposable element analysis in -omics data, and Transposable elements in Aging: from biomarkers to effectors. Together, these contributions provide valuable insights into the mechanisms and impacts of transposable element activity, advancing our understanding of their broad significance in genetics, development, health, and disease.