This volume covers the new methodological advances in NMR spectroscopy that have been developed since the publication of the first edition. These include: 'indirect detection' methods, particularly proton-detected carbon-13 spectra, which have profoundly increased NMR sensitivities; 3- and even higher- dimensional NMR methods which have further increased spectral resolving and correlating power; powerful new computer programs which assist in all phases of data analysis and ultimately make possible rigorous interpretations of complex 2D and higher- dimensional NMR spectra using molecular mechanics and dynamics calculations; and field gradient technology which makes it possible to acquire 2D and higher-dimensional spectra of concentrated samples very rapidly, greatly reducing experiment times. This new edition retains the original format of the first edition with introductory chapters covering descriptions, basic theoretical treatments and experimental aspects of the methods. These are followed by applications chapters representing a broad sampling of important research areas and compound classes