This book illustrates effective decision-making in complex socio-economic systems utilising system dynamics and agent-based simulation modelling approaches. It provides practical guidance on the application of conceptual and numerical modelling and simulation for analysing economic, strategic, regulatory, sociological and ethical questions from a complex systems perspective. Its theoretical, methodological and practical illustrations will enhance readers’ understanding of the application of simulation modelling for effective systems management. By virtually experimenting with alternative management scenarios, it will help them improve decision-making and control mechanisms. The book explores practical examples from the fields of pharmaceuticals, healthcare, finance, sociology, education and culture from a strategic, regulatory and ethics perspective. As such, it offers a valuable resource for managers, both at for-profit corporations and non-profit organisations, public policymakers and regulators alike.