This book aims to contribute to the transdisciplinary study of the water-energy-food (WEF) nexus in cities and to help policy makers adopt a more integrated approach to natural resources management in urban environments to face the challenges and threats of climate change. This approach is based on a multidimensional scientific framework that seeks to understand the complex and non-linear interrelationships and interdependencies between water-energy-food under climate change and to generate solutions to reduce trade-offs among development goals and generate co-benefits that help encourage sustainable development and contribute to the achievement of SDGs, mainly SDG 11 (make cities and human settlements inclusive, safe, resilient and sustainable) and SDG 13 (take urgent action to combat climate change and its impacts). Governing the WEF nexus in cities is one of the greatest resource challenges of our time, as cities consume large amounts of WEF, but one that can also generate relevant alternatives with which to tackle climate change. To help fostering these alternatives, this book analyzes the governance, institutional and political economy factors that determine the effectiveness of the nexus approach and reviews the potential, the benefits and the policy implications of the adoption of the WEF nexus approach at the urban level. Through a series of hands-on cases, chapters in this book present the opportunities of the WEF nexus approach to achieve innovation and transformative change and discuss concrete areas of synergy and policy initiative to raise urban resilience. Water-Energy-Food Nexus and Climate Change in Cities will serve both as a guide for policy makers as well as a useful resource for students and researchers in fields such as urban studies, public health, environmental sciences, energy studies and public policy interested in learning how cities can represent possibilities to navigate and manage sustainability from local to global.