When the Brain Can't Cope: Introducing Brain Fatigue Syndrome is a groundbreaking book pioneering the clinical condition of Brain Fatigue Syndrome, characterized by cognitive, emotional, and sensory impairment and profound exhaustion after mental activity that is not relieved by rest or sleep. It offers a thorough description, including its relationship to other pathologies and symptoms, method of study and recognition, and comprehensive management. The book defines and describes brain fatigue, outlining how it can be assessed. Presenting a pathophysiological explanation at the cellular level, the authors also include research-based treatment strategies aimed at improving daily functioning and quality of life. To bring visibility to this often “invisible” condition, personal stories from individuals living with brain fatigue are incorporated, along with practical and real-life examples to raise awareness of the reality of this complex syndrome. It is valuable reading for students of neuropsychology, medicine, nursing, and occupational therapy, as well as various healthcare professionals who work in the field of neurorehabilitation for acquired brain damage and those in primary care settings.