San Francisco, 28 Barbary Lane, Anna Madrigal runs a boarding house. She welcomes people who have nowhere else to go: the misfits. This matriarch is known for her unending kindness and her superb marijuana crop. The novel starts with the arrival of Mary Ann Singleton, a prudish, naive, young woman who escaped her dull Ohio hometown for San Francisco. She settles in with her other fellow tenants: Michael "Mouse," a personable young gay man, Brian Hawkins, an incorrigible Don Juan, and Mona Ramsey, a young hippyish bisexual.