This book explores in detail the AI-driven cyber threat landscape, including inherent AI threats and risks that exist in Large Language Models (LLMs), Generative AI applications, and the AI infrastructure. The book highlights hands-on technical approaches to detect security flaws in AI systems and applications utilizing the intelligence gathered from real-world case studies. Lastly, the book presents a very detailed discussion of the defense mechanisms and practical solutions to secure LLMs, GenAI applications, and the AI infrastructure. The chapters are structured with a granular framework, starting with AI concepts, followed by practical assessment techniques based on real-world intelligence, and concluding with required security defenses. Artificial Intelligence (AI) and cybersecurity are deeply intertwined and increasingly essential to modern digital defense strategies. The book is a comprehensive resource for IT professionals, business leaders, and cybersecurity experts for understanding and defending against AI-driven cyberattacks.