This volume is based on the 2008 Clifford Lectures on Information Flow in Physics, Geometry and Logic and Computation, held March 12-15, 2008, at Tulane University in New Orleans, Louisiana. The varying perspectives of the researchers are evident in the topics represented in the volume, including mathematics, computer science, quantum physics and classical and quantum information. A number of the articles address fundamental questions in quantum information and related topics in quantum physics, using abstract categorical and domain-theoretic models for quantum physics to reason about such systems and to model spacetime. Readers can expect to gain added insight into the notion of information flow and how it can be understood in many settings. They also can learn about new approaches to modeling quantum mechanics that provide simpler and more accessible explanations of quantum phenomena, which don't require the arcane aspects of Hilbert spaces and the cumbersome notation of bras and kets.