The textbook is intended for teaching MATLAB language and its applications. The book is composed of three parts: MATLAB programming, scientific computing with MATLAB, and system simulation with Simulink. Since MATLAB is widely used in all fields of science and engineering, a good introduction to the language can not only help students learn how to use it to solve practical problems, but also provide them with the skills to use MATLAB independently in their later courses and research. The three parts of the book are well-balanced and tailored to the needs of engineering students, and the mathematical problems commonly encountered in engineering can be easily solved using MATLAB. This textbook is suitable for undergraduate and graduate students majoring in science and engineering. The study guide of this textbook could be accessed via: http://sn.pub/thGR7v. This website provides links to recorded teaching videos, MATLAB toolbox for the book, interactive slide decks files in Powerpoint documents, and solution manuals by the authors.