This book provides a hands-on experience in software and hardware development of IoT devices in edge and cloud computing systems, by putting concepts of networking and computing software with devices and hardware in practice. It proposes a Network of Things engineering (NoTE) Lab, with seven hand-on lab modules, ranging from labs on “Interfacing sensors and actuators” and “Connecting IoT and Edge with MQTT,” over to “Integrating sensors and actuators with edge and cloud tools”. In IoT context, it uses Arduino based boards that support a variety of low-cost sensors and actuators.  In the edge computing context, NoTE Lab implements off-the-shelf single board computers, Raspberry Pis with corresponding software and hardware. In the cloud context, a few well-known and widely used cloud computing open-source tools, for example, Kubernetes, where readers can learn the basics of monitoring and managing containers in cloud computing designed for undergraduate and graduate course levels. This book is easy to follow and all tools and software used in this book are free, open source, and available to the readers.