First published in 1992. This is Volume 12, number 3 of Psychoanalytic Inquiry 1992 which looks at the integration of neuroscience and clinical science. The five essays in this issue of Psychoanalytic Inquiry both review progress to date and, more relevantly, continue to show how data and concepts from cellular neurobiology, experimental psychology, ethology, and cognitive science may illuminate long-familiar clinical phenomena and observations.