The second edition of this book offers an overview of the percutaneous techniques and technologies most frequently employed in structural heart intervention, focusing on patient selection, preoperative evaluation, choice of available devices and outcome optimization. Interventional procedures for aortic stenosis, mitral regurgitation, left atrial appendage closure, patent foramen ovale closure, and closure of interatrial and interventricular defects are presented in a step by step fashion, and paralleled by informative illustrations. This new edition of Percutaneous Intervention for Structural Heart Disease aims to adjourn the reader on structural heart intervention not only as per current standard practice, but also on uprising topics such as percutaneous treatment of tricuspid regurgitation and paravalvular leak closure. Advances made in recent years, including introduction and optimization of transcatheter aortic valve implantation in patients with severe aortic stenosis independently from estimated surgical risk and implementation of percutaneous edge-to-edge mitral valve repair for functional mitral regurgitation, will be taken into account. The authors are all acknowledged experts with extensive experience in catheterization laboratories and surgical operating rooms.