Qualitative research methods are essential for addressing central questions arising from clinical and organisational practice. In medicine and healthcare, knowing and scientific knowledge cannot be reduced to what is measurable alone. It also depends on subjectivity, interpretation, clinical reasoning, interaction and ethical judgement. This book develops a coherent methodological framework in which these dimensions are understood as integral to knowledge development rather than as residual or secondary concerns. The opening chapters establish the philosophical foundations for a qualitative methodology grounded in healthcare practice and distinctly committed to the epistemic impact of subjectivity. Ontological assumptions about health and illness are madeexplicit and systematically linked to epistemological and methodological choices. Subsequent chapters guide the reader through the core stages of the research process—from design and data development to analysis and interpretation—consistently demonstrating how underlying assumptions shape methodological strategies and conclusions. Empirical examples illustrate methodological reasoning, critical decisions and common pitfalls. Unlike many introductory texts, this book treats subjectivity, clinical judgement and interpretation not as threats to scientific rigour, but as indispensableresources for knowledge development. Rather than offering a broad survey of qualitative traditions, it presents a coherent, practice-based approach that affirms the scientific legitimacy of qualitative research on its own terms. Written primarily for students and researchers new to qualitative methods at bachelor’s, master’s and doctoral levels in medicine and healthcare, the book also invites more experienced scholars to reflect critically on established methodological practices.