This book consistutes the revised selected papers of the First International Conference on Sustainable Innovations in Statistics and Data Science, SISD 2025, held in Bangalore, India, during March 27-28, 2025. The 23 papers included in these proceedings were carefully reviewed and selected from 264 submissions. The research presented covers a broad spectrum of themes, including statistical modeling, artificial intelligence, machine learning, health analytics, financial analytics, climate informatics, and sustainable development.