This edited volume demonstrates how African philosophy can offer new ways to understand transhumanism and moral enhancement, which involve improving humans' moral, emotional, and cognitive capacities, genes, and physical abilities through scientific and technological interventions. These interventions aim to help individuals overcome some (if not all) biological and natural limitations, such as diseases, ageing, and even death, in order to become transhumans and posthumans. The volume considers how African values can either support and/or challenge transhumanism and moral enhancement from African philosophical perspectives. For example, one might defend moral enhancement by imagining a posthuman future in Africa or argue that it truncates the process of acquiring personhood within the African philosophical context. This volume is of great benefit to researchers, professionals, and students interested in exploring the prospects and challenges of transhumanism and moral enhancement from a perspective beyond the Western worldview.