This volume offers a foundational resource for understanding, practicing, and teaching interdisciplinarity in biblical studies, fostering informed, reflective, and critically responsible engagement across disciplinary boundaries. Part I explores the conceptual, ethical, and pedagogical dimensions of interdisciplinarity, providing readers with conceptual tools for assessing how interdisciplinary approaches are articulated, justified, and implemented within biblical scholarship, while also attending to questions of academic formation, institutional practices, and even ethical standards. Part II provides introductory overviews of major disciplinary intersections with biblical studies. Each chapter introduces a specific field—ranging from Papyrology and Literary Studies to Cognitive Science and Digital Humanities—and includes a worked example that demonstrates how that discipline can be applied to the biblical corpus. Taken together, the contributions to this Handbook offer a panoramic view of the contemporary interdisciplinary landscape in biblical studies. The Routledge Handbook of Interdisciplinary Approaches to Biblical Studies is a comprehensive reference work suitable for students and scholars working in all areas of biblical studies, particularly those who are unfamiliar with interdisciplinarity or who wish to explore new avenues in their research.