This book investigates the geopolitics and strategic dimensions of US-American foreign policy during George W. Bush's and Barack Obama's presidential terms. Based on a vast amount of empirical and historical sources, the author offers deep insights into the recent political developments ('Arabellions') along the axis of Northern Africa, the Middle East, and Central Asia, situating them in the context of the global geopolitical and geo-economical Great Game, either latent or overt, between USA/NATO and Russia. The author also analyses the influence of the US on these historical and political processes in the last two decades.