In the ever-evolving field of Upper Gastrointestinal (UGI) and Hepato-Pancreato-Biliary (HPB) surgery, staying informed about the pivotal research that shapes clinical practice is essential. 50 Landmark Papers every Upper GI and HPB Surgeon Should Know is a carefully curated collection of influential studies that have transformed decision-making in the management of complex conditions. From groundbreaking insights into cancers of the stomach, liver, and pancreas to the management of bile duct injuries, hiatus hernia, and pharyngeal pouch, this book highlights the research that has redefined surgical approaches. It also delves into the historical significance of interdisciplinary collaboration, such as the creation of GI bleeding units, and includes key papers on endoscopic management and ERCP, reflecting the evolving role of surgeons in these areas. Organized into focused sections—gallbladder, liver, pancreas, stomach, bile duct, oesophagus, endoscopic treatment, obesity, and general topics—this book serves as a practical guide for surgeons and trainees alike. Each paper has been selected for its impact on clinical practice, offering a foundation for understanding the evidence that underpins modern surgical care. Whether you are a seasoned surgeon or a trainee, this book will inspire you to explore the evidence, challenge established norms and strive for excellence in the dynamic field of Upper GI and HPB surgery.