This volume provides methods for the analysis of ADAMTS proteases and ADAMTS-like proteins. Chapters detail ADAMTS family members, with special attention to the exciting progress made in understanding ADAMTS13—its biology, disease mechanisms, detection, and clinical management of a potentially fatal thrombotic microangiopathy, thrombotic thrombocytopenic purpura (TTP). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, ADAMTS Proteases: Methods and Protocol is a valuable resource for any researcher hoping to contribute to the ever expanding world of ADAMTS.