This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an MSC cruise ship navigating the Mediterranean Sea. It particularly highlights Horizon 2020 projects, covering topics such as novel synthetic strategies for nanomaterials, the implementation of bio- and smart materials for pharmacological and medical purposes, as well as environmental applications. Intended for a broad audience of academics and professionals, it offers a comprehensive and timely snapshot of the field of biomaterials. In addition to a set of innovative theories together with the necessary practical tools for their implementation, it also addresses the current challenges in the field, fostering new discussions and possible future collaborations between diverse groups.