This book constitutes the refereed proceedings of the 16th Colombian Congress on Computing, CCC 2022, held in Armenia, Colombia, during October 17–21, 2022The 12 full papers included in this book were carefully reviewed and selected from 40 submissions. They topics of this volume include software engineering and IT architecture, human-computer interaction, cybersecurity and information security, image processing and computer vision, multimedia, artificial intelligence and robotics, education and ICT, data, information and knowledge, distributed systems and large-scale computing, and formal methods in computer systems, among others.