This book constitutes the proceedings of the 19th International Symposium on Intelligent Data Analysis, IDA 2021, which was planned to take place in Porto, Portugal. Due to the COVID-19 pandemic the conference was held online during April 26-28, 2021.The 35 papers included in this book were carefully reviewed and selected from 113 submissions. The papers were organized in topical sections named: modeling with neural networks; modeling with statistical learning; modeling language and graphs; and modeling special data formats.