This book reports on the German research initiative AeroStruct, a three-year collaborative project between universities and the aircraft industry. It describes the development of an integrated multidisciplinary simulation environment for aircraft analysis and optimization using high-fidelity methods. This system is able to run at a high level of automatism, thus representing a step forward with respect to previous ones. Its special features are: a CAD description that is independent from the disciplines involved, an automated CFD mesh generation and an automated structure model generation including a sizing process. The book also reports on test cases by both industrial partners and DLR demonstrating the advantages of the new environment and its suitability for the industry. These results were also discussed during the AeroStruct closing Symposium, which took place on 13-14 October 2015 at the DLR in Braunschweig, Germany. The book provides expert readers with a timely report on multidisciplinary aircraft design and optimization. Thanks to a good balance between theory and practice, it is expected to address an audience of both academics and professional, and to offer them new ideas for future research and development.