This book is a collection of papers compiled from the conference "Algorithms and Computer-Based Solutions" held on June 8-9, 2021 at Peter the Great St. Petersburg Polytechnic University (SPbPU), St. Petersburg, Russia. The authors of the book are leading scientists from Russia, Germany, Netherlands, Greece, Hungary, Kazakhstan, Portugal, and Poland. The reader finds in the book information from experts on the most interesting trends in digitalization - issues of development and implementation of algorithms, IT and digital solutions for various areas of economy and science, prospects for supercomputers and exo-intelligent platforms; applied computer technologies in digital production, healthcare and biomedical systems, digital medicine, logistics and management; digital technologies for visualization and prototyping of physical objects. The book helps the reader to increase his or her expertise in the field of computer technologiesdiscussed.