Reflecting the growth in the field and the heightened focus on select areas, this volume updates a classic text and captures the current state and future direction of technologies in combinatorial chemistry. Topics discussed include: properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling. It also covers Fourier transform infrared techniques, on-support mass spectrometry, nuclear magnetic resonance methods used in the reaction optimization stage, and combinatorial library analysis using spectrophotometric, fluorometric, and other methods.