This book constitutes the refereed joint proceedings of the 18th International Symposium on Artificial Intelligence and Mathematics, ISAIM 2024, and the 22nd International Workshop on Combinatorial Image Analysis, IWCIA 2024, held in Fort Lauderdale, FL, USA, during January 8–10, 2024. The 14 full papers presented were carefully reviewed and selected from 25 submissions. The papers cover topics from AI, theoretical computer science, mathematics, medicine, robotics, defense, and security.