This book constitutes the refereed proceedings of the 18th International Conference on Artificial Intelligence: Methodology, Systems, and Applications, AIMSA 2018, held in Varna, Bulgaria, in September 2018. The 22 revised full papers and 7 poster papers presented were carefully reviewed and selected from 72 submissions. They cover a wide range of topics in AI: from machine learning to natural language systems, from information extraction to text mining, from knowledge representation to soft computing; from theoretical issues to real-world applications.